pI: 6.2118 |
Length (AA): 123 |
MW (Da): 13924 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_127737)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G29340 | profilin 4 |
Arabidopsis thaliana | AT2G19760 | profilin 1 |
Arabidopsis thaliana | AT2G19770 | profilin 5 |
Arabidopsis thaliana | AT4G29350 | profilin 2 |
Arabidopsis thaliana | AT5G56600 | profilin 3 |
Brugia malayi | Bm1_21620 | Profilin family protein |
Candida albicans | CaO19.12542 | can functionally substitute for S. cerevisiae actin-binding protein profilin (PFY1/YOR122C) which |
Candida albicans | CaO19.5076 | can functionally substitute for S. cerevisiae actin-binding protein profilin (PFY1/YOR122C) which |
Caenorhabditis elegans | CELE_Y18D10A.20 | Protein PFN-1 |
Caenorhabditis elegans | CELE_K03E6.6 | Protein PFN-3 |
Dictyostelium discoideum | DDB_G0287125 | profilin I |
Dictyostelium discoideum | DDB_G0271142 | profilin III |
Dictyostelium discoideum | DDB_G0286187 | profilin II |
Drosophila melanogaster | Dmel_CG9553 | chickadee |
Echinococcus granulosus | EgrG_000122100 | Profilin allergen |
Entamoeba histolytica | EHI_176140 | profilin, putative |
Entamoeba histolytica | EHI_109900 | profilin, putative |
Echinococcus multilocularis | EmuJ_000122100 | Profilin allergen |
Homo sapiens | 375189 | profilin family, member 4 |
Leishmania braziliensis | LbrM.32.0570 | profilin, putative |
Leishmania donovani | LdBPK_320550.1 | profilin, putative |
Leishmania infantum | LinJ.32.0550 | profilin, putative |
Leishmania major | LmjF.32.0520 | profilin, putative |
Leishmania mexicana | LmxM.31.0520 | profilin, putative |
Loa Loa (eye worm) | LOAG_01822 | hypothetical protein |
Loa Loa (eye worm) | LOAG_04692 | profilin |
Mus musculus | ENSMUSG00000020639 | profilin family, member 4 |
Oryza sativa | 4348317 | Os10g0323900 |
Oryza sativa | 4340155 | Os06g0152100 |
Oryza sativa | 4348316 | Os10g0323600 |
Onchocerca volvulus | OVOC2290 |
|
Saccharomyces cerevisiae | YOR122C | profilin |
Schmidtea mediterranea | mk4.000776.05 | |
Trypanosoma brucei gambiense | Tbg972.11.15400 | profilin, putative |
Trypanosoma brucei | Tb927.11.13780 | profilin |
Trypanosoma congolense | TcIL3000.11.14170 | profilin |
Trypanosoma cruzi | TcCLB.510911.10 | profilin, putative |
Trypanosoma cruzi | TcCLB.458759.10 | profilin, putative |
Trichomonas vaginalis | TVAG_242860 | profilin, putative |
Trichomonas vaginalis | TVAG_454630 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.5350 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.5350 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.5350 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.01.5350 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y18D10A.20 | Caenorhabditis elegans | embryonic lethal | wormbase |
YOR122C | Saccharomyces cerevisiae | inviable | yeastgenome |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.